Convergen LifeSciences Announces Patent Award for Cancer Suppressors
, Chief Operating and Financial Officer, Convergen LifeSciences. "By taking the novel tumor suppressors and assembling technologies from the fields of genomics, nanotechnology, molecular medicine and advanced materials sciences, we have built the foundation for a number of potential new therapies which may provide new options for cancer patients."The patent pertains to the discovery that chromosome 3p21.3 genes act as cancer suppressors. Loss of tumor suppression function in this chromosomal hotspot is known to be associated with the early onset of cancers. Genes within this region induce apoptosis or programmed cancer cell death of cancer cells, and act to control cell signaling and inflammation. The most potent apoptotic tumor suppressor within the 3p21.3 family was determined to be TUSC2, also known as FUS1. TUSC2 aberrations are found in breast, ovarian, liver and other cancers and are associated with more than 80% of lung cancers. TUSC2 works to kill cancer cells without harming normal cells. In CNVN202, TUSC2 is incorporated into lipid nanoparticles, which when administered intravenously, target cancer cells throughout the body. Promising results from a phase I dose escalation clinical trial testing CNVN202 (DOTAP:chol-TUSC2) monotherapy in recurrent and metastatic lung cancer patients were reported at the 2011 Annual Meeting of the American Association for Cancer Research.
The trial showed for the first time that a tumor suppressor gene can be delivered intravenously and selectively to human cancer cells using a nanoparticle vector, express high levels of mRNA and protein in cancer cells in the primary tumor and distant metastatic sites, alter relevant pathways in the cancer cell and mediate clinically beneficial anti-cancer activity.
A phase II clinical trial is planned to evaluate CNVN202 in combination with Tarceva® (erlotinib) in lung cancer patients, who would not be expected to benefit from erlotinib alone. CNVN202 has shown synergy when combined with erlotinib in both EGFR mutation positive and negative cancers. Tarceva® is a registered trademark of the Roche Group and Astellas Pharma . Tarceva® is marketed by The Roche Group , including its members Genentech in the U.S. and Chugai in and by Astellas Oncology in the U.S.
About Convergen LifeSciences
Convergen LifeSciences, Inc. is a privately held, clinical-stage biopharmaceutical company developing personalized, pathway-targeted treatments designed to be more effective and less toxic than currently available cancer treatments. By using its technologies to overcome drug resistance and unlock the unrealized potential of currently marketed cancer drugs, the company is working to expand targeted clinical populations for these existing cancer drugs to include patients who cannot currently benefit from available drugs due to genomic limitations.
Texas Board Of Medicine - News
AUSTIN, Texas, June 28, 2011 /PRNewswire/ -- Convergen LifeSciences, Inc. announced today that a United States Patent has been awarded by the US Patent and Trademark Office jointly to The University of Texas System Board of Regents and The Secretary,
Forensic pathologists like McClain play a critical role at the intersection of medicine and law enforcement. Employed by medical examiners and coroners' offices, they are called in to figure out how people have died. They scrutinize corpses, searching
Dr. Pryor is a Temple, Texas native who is board certified by the American Board of Pediatrics, as well as a Fellow of the American College of Chest Physicians and The American College of Critical Care Medicine. A graduate of Baylor University in Waco,
Dr. Kini was one of 175 hospitalists across the nation who were inducted as Fellows in May at SHM's Hospital Medicine 2011 conference in Dallas, Texas. Dr. Kini serves as medical director, Hospital Division, RMH Medical Group, which includes
She became the first Hispanic to be named a dean of a nursing program in El Paso – that was at El Paso Community College – and she is also the first Hispanic to be appointed to the Texas Board of Nursing, which governs the 338000 nurses in the state.
Could It Be? Texas and Nevada to Create Boards of Integrative ...
Complementary and alternative medicine. Because they have a different approach, they mistrust CAM, and this contributes to a hostile environment on state medical boards. How can they fairly ascertain the state of affairs if they don’t understand the integrative approach or utilize it themselves? Because of this, state medical boards regularly favor conventional treatments , with complementary and alternative treatments being denigrated or worse. Integrative practitioners face personal attacks by medical boards, and it is an uphill battle to defend their practice, as we have reported to you previously. Some states, like Texas, have some strong due process protections for doctors , but rules are not always followed if the medical board itself is biased. HB2455 could be an important step towards evening that playing field. It creates a board exclusively for integrative medicine, which will consist of “six members who are physicians and who practice integrative medicine”—and who, therefore, will have a full and unbiased understanding of CAM—and three members who represent the public and are not licensed or trained in a healthcare profession. The bill defines “integrative medicine” as “a medical system of diagnosing, treating, or correcting real or imagined human diseases, injuries, ailments, infirmities and deformities of a physical or mental origin and includes acupuncture, chelation therapy, homeopathy, minor surgery, and nonsurgical methods, the use of devices, physical, electrical, hygienic, and sanitary measures, and all forms of physical agents and modalities, neuromuscular integration, nutrition, orthomolecular therapy, and pharmaceutical medicine.” There’s a second bill in Texas that is exciting as well. HB1013 , which relates to the powers and duties of the Texas Medical Board. It includes provisions such as banning anonymous complaints against doctors, and guaranteeing jury trials for doctors whose licenses are being revoked. Generally, it gives more due process rights for all doctors, including doctors who practice integrative medicine. The ban on anonymous complaints is important because doctors will sometimes lodge anonymous and false complaints on other doctors to get rid of their competition. A jury trial is important, because it allows for an independent review outside of a potentially biased board.
I whole heartedly agree with the state bills to establish integrative state medicine boards, but I disagree with banning anonymous complaints. Even though the Texas state medical board allows for anonymous complaints, two Texas nurses, who made anonymous complaints about the unsafe practices of a physician who had previously been under state board review, were arrested, charged, and fired. After much time and expensive legal representation they have been cleared of felony misuse of official information, yet they have since been unable to find jobs.
Texas Board Of Medicine - Bookshelf
Texas State journal of medicine
Medical Department, Fort Worth University 191 192 University of Texas, Department of Medicine 168 189 Baylor University College of Medicine 132 70 Gate City ...JAMA., The Journal of the American Medical Association
TEXAS Texas, population 3096542 lias four medical colleges. The University of Texas Department of Medicine is located at Galveston, a city of 36981 ...Texas reports, cases argued and decided in the Supreme Court of the State of Texas
... Revised Statutes, which reads as follows, "Said board of medical examiners shall be ... the qualifications of practitioners of medicine in this State, ...Head and neck surgery--otolaryngology
... Ohio CHARLOTTE D. JACOBS, MD Professor, Department of Medicine, ... Oral Medicine, Oral Pathology, Department of Pathology, University of Texas Health ...Women pioneers in Texas medicine
In 1873, the Texas Legislature produced a law that established a board of examiners in each county and required a practitioner of medicine to have either a ...Everyday News Directory
Texas Medical Board
State agency that licenses, regulates, and disciplines physicians, physician assistants and acupuncturists.
Texas Medical Board
Texas Medical Board. The Texas Medical Board is the state agency mandated to regulate the practice of medicine by M.D.'s and D.O.'s in Texas. ...
Texas State Board of Podiatric Medical Examiners
Lists board members and meetings, complaint procedure, and information about licensing and continuing education.
Texas Medicine Magazine
Contents of most recent issue of Texas Medicine and general information about the magazine.
Texas Medical Licensing Service
Texas Medical Licensing Service's specialization is Licensing and Recruitment of Physicians to the State of Texas. Over 2,000 Physicians licensed and counting.